学術論文　　和文総説

2009

Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M.: The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol 29:493-502.
Keap1-Nrf2システムが多種多様の化学物質やストレスに応答できるのは、複数のセンサー機構をもつからと提唱し実証した論文。 11種のNrf2活性化分子を、センサー機構の違いにより6クラスに分類した。ストレス応答に異常をもつ突然変異ゼブラフィッシュ系統の開発も紹介。システインコード仮説も提唱。

Mukaigasa K, Hanasaki A, Maeno M, Fujii H, Hayashida SI, Itoh M, Kobayashi M, Tochinai S, Hatta M, Iwabuchi K, Taira M, Onoe K, Izutsu Y.: The keratin-related Ouroboros proteins function as immune antigens mediating tail regression in Xenopus metamorphosis. Proc Natl Acad Sci USA 106:18309-18414.
新潟大の井筒先生との共同研究。カエル変態時のしっぽの消失は、実は、カエル成体の免疫機構が、しっぽに残るオタマジャクシの抗原を認識して、攻撃することを実証した画期的な論文。単離した抗原遺伝子を、ウロボロスという古代ギリシャの「自分の尾を飲み込む蛇」にちなんで命名。

2008

Li L, Kobayashi M, Kaneko H, Nakajima-Takagi Y, Nakayama Y, Yamamoto M.: Molecular evolution of Keap1: Two Keap1 molecules with distinctive IVR structures are conserved among fish. J Biol Chem 283:3248-3255.
2種のゼブラフィッシュKeap1を同定・解析した論文。ともにNrf2を分解促進して抑制できることと、ホモ及びヘテロダイマーを形成できることを実証した。システイン残基の保存性に着目して、Keap1の進化について考察した。

2007

Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M.: Gata-1 self-association controls erythroid development in vivo. J Biol Chem 282:15862-15871. 

Kobayashi M, Yamamoto M.: Regulation of GATA1 gene expression. J Biochem 142:1-10. 

2006

Kobayashi M, Yamamoto M.: Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Reg 46:113-140.

2005

Suzuki T, Takagi Y, Osanai H, Li L, Takeuchi M, Katoh Y, Kobayashi M, Yamamoto M.: Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish. Biochem J 388:65-73.

Ando H, Kobayashi M, Tsubokawa T, Uyemura K, Furuta T, Okamoto H.: Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. Dev Biol 287:456-468.

Kobayashi M, Yamamoto M.: Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7:385-394. 

2004

Takagi Y, Kobayashi M, Li L, Suzuki T, Nishikawa K, Yamamoto M.: MafT, a new member of the small Maf protein family in zebrafish. Biochem Biophys Res Commun 320:62-69. 

Kimura-Yoshida C, Kitajima K, Oda-Ishii I, Tian E, Suzuki M, Yamamoto M, Suzuki T, Kobayashi M, Aizawa S, Matsuo I.: Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for the vertebrate head specification. Development 131:57-71.

Kawakami K, Takeda H, Kawakami N, Kobayashi M, Matsuda N, Mishina M.: A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Dev Cell 7:133-144.

2003

Nishikawa K, Kobayashi M, Masumi A, Lyons SE, Weinstein BM, Liu PP, Yamamoto M.: Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Mol Cell Biol 23:8295-8305.

2002

Kobayashi M, Itoh K, Suzuki T, Osanai H, Nishikawa K, Katoh Y, Takagi Y, Yamamoto M.: Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 7: 807-820.

Kobayashi D, Kobayashi M, Matsumoto K, Ogura T, Nakafuku M, Shimamura K.: Early subdivisions in the neural plate define distinct competence for inductive signals. Development 129:83-93. 

2001

Kobayashi M, Nishikawa K, Yamamoto M.: Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish embryos. Development 128:2341-2350 

Kobayashi M, Nishikawa K, Suzuki T, Yamamoto M.: The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. Dev Biol 232:315-326.

Kajihara M, Kawauchi S, Kobayashi M, Ogino H, Takahashi S, Yasuda K.: Isolation, characterization, and expression analysis of zebrafish large Mafs. J Biochem 129:139-146. 

2000

Kobayashi M, Osanai H, Kawakami K, Yamamoto M.: Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites. Mech Dev 98:151-155.